Our researchers - Professor Sophie Hambleton

Sophie Hambleton is a clinician scientist who leads the Primary Immunodeficiency Group at Newcastle University and plays an active part in the paediatric immunology service at the Great North Children's Hospital. Her group studies the molecular basis of novel inborn errors of the immune system, with a focus on susceptibility to intracellular pathogens and immune dysregulation. Their discoveries include isolated viral susceptibility arising from defective type I interferon signalling, the first examples of dendritic cell deficiency in humans, and novel monogenic causes of complex autoimmunity and combined immunodeficiency in childhood.

Sophie has been an enthusiastic adopter of next generation sequencing and she leads the Genomics England Clinical Interpretation Partnership for Immune Disorders.