Prior SARS-CoV-2 infection is associated with protection against symptomatic reinfection

10.1016/j.jinf.2020.12.023

Journal of Infection

7th January 2021

Contributing to research themes:

"It has been recently suggested that prior exposure to seasonal coronaviruses might confer cross-protection against SARS-CoV-2. Whether SARS-CoV-2 infection itself confers immunity to reinfection has not been established. Immunity is probable, at least in the short term, because reinfections are infrequently reported, despite over 55 million primary infections occurring worldwide since December 2019. Protection against short term reinfection has been observed in a non-human primate model of SARS-CoV-2. A small clinical study was also suggestive. Immunity to seasonal coronaviruses is maintained for up to 12 months. The second wave of SARS-CoV-2 transmission provides an opportunity to detect early signals of immunity. We previously defined a large cohort of over 11,000 healthcare workers (HCWs) with documented evidence of previous infection status during the first wave of the SARS-CoV-2 pandemic, from March to April 2020. A second wave of SARS-CoV-2 transmission occurred in our setting from October to November 2020, approximately 7 months later. We undertook a retrospective analysis of HCW testing data during this second wave, to address the question of whether previous SARS-CoV-2 infection was associated with protection. ..."

Read the full article here.

Author list:

Aidan T. Hanrath, MBBS; Brendan A.I. Payne, PhD; Christopher J.A. Duncan*, DPhil; The NUTH HCW Testing Group; Ina Schim van der Loeff; Kenneth F. Baker; David A. Price; Peter McDowall; Kiera McDowall; Sue Cook; Peter Towns; Ulrich Schwab; Adam Evans; Jill Dixon; Jennifer Collins; Shirelle Burton-Fanning; David Saunders; Jayne Harwood; Julie Samuel; Matthias L. Schmid; Lucia Pareja-Cebrian; Ewan Hunter; Yusri Taha; Elizabeth Murphy

∗Corresponding author at: Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom