Our researchers - Professor Manu Shankar-Hari

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Professor Manu Shankar-Hari

NIHR Clinician Scientist

King’s College London

Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, UK


Research group website

Contributing to research themes:

Shankar-Hari group’s research explores ways to improve outcomes in adult critically ill patients with sepsis and with ARDS, by linking the illness immunobiology with novel interventional trial designs.
My lab’s focused research themes are
1.    Immunobiology: Explore adaptive immune system changes in critically ill patients (e.g. sepsis, ARDS). We integrate orthogonal multilevel data with repeated measurements of cellular phenotype, functional assessments, alongside corresponding transcriptomes and epigenetic landscapes.
2.    Stratified medicine: We use early-phase randomised controlled trials, cohort studies, systematic reviews and large clinical trial datasets to (a) explore treatment effect heterogeneity; (b) identify treatable traits based on dominant biological mechanisms, and (c) modifiable proximate determinants of sepsis and ARDS.
3.    COVID immunology in adults and in children in PIMS-TS

For further details, please see webpage: https://www.kcl.ac.uk/research/shankar-hari-group